(Photo credit: Gregory Fisher-Imagn Images)

Isaac McKneely drilled seven 3-pointers to help No. 6 Louisville build a big lead and hold off No. 11 South Florida 83-79 on Thursday in an NCAA Tournament first-round matchup at Buffalo, N.Y.

McKneely matched his season high of 23 points on 8-of-11 shooting. Ryan Conwell added 18 points with six assists and Sananda Fru notched a double-double with 10 points and 10 rebounds for the Cardinals (24-10), who won their first NCAA Tournament game since 2017.

Joseph Pinion (career-high 27 points) and Izaiyah Nelson (22) scored 22 and 15 points, respectively, in the second half as the Bulls (25-9) shot 47.6% after halftime but saw their 11-game win streak snapped.

South Florida's leading scorer, Wes Enis (16.8 points per game), managed just four points on 2-of-15 shooting, including 0-for-11 from 3-point range. The Bulls made just 5 of 33 perimeter shots (15.2%).

The Cardinals, who shot 53.8% from the floor and 52% from 3-point range, appeared destined for a stress-free victory when they led by 22 with 11:23 left. But they got careless with the ball, committing 10 of their season-high 22 turnovers over the final 9:39.

The Bulls cut that deficit to six points with 1:58 left. Pinion missed a pair of 3-pointers in the final 90 seconds that could have made it a three-point game.

After a slow start from both teams, Louisville took command with a 17-6 run, highlighted by 3-pointers from four different players, to jump ahead 24-11 with 8:31 left in the half.

The Bulls missed 12 straight shots during that stretch to start 4-of-24 from the floor. South Florida heated up a small bit but still shot just 28.6% from the floor, including a ghastly 1-of-17 from 3-point range, as the Cardinals took a 37-27 lead into the intermission.

McKneely led Louisville with 11 first-half points anchored by making 3 of 4 threes. Nelson led South Florida with seven points.

After the Bulls cut the deficit to eight points early in the second half, the Cardinals again responded, this time going on a 16-4 surge to push their advantage to 20 with 14:26 left.

--Field Level Media